Author: BigGuy

Your Monday Morning Score Card

Coronavirus 5, Taliban 10, President Biden -5. In this edition of Radio Free Wall Street we’ll take a long, sober look at the issues we face.

Vitamin D deficiency (VDD) partly explains geographical differences in COVID-19 susceptibility, severity, and mortality. VDD among African-Americans, diabetics, hypertensive, and aged populations possibly explain the higher death rate, aggravated by cocooning. Vitamin D is pleiotropic, mediating bone metabolism, calcium homeostasis, and immune functions, whereas VDD is associated with inflammatory reactions and immune dysfunction, predisposing individuals to severe infections. Vitamin D modulates innate and adaptive immunity via the expression of genes that code antimicrobial peptides (AMPs). And the expression of cluster of differentiation (CD)14, the co-receptor for epidermal toll-like receptor (TLR)4. AMPs stimulate TLR2 in macrophages, increasing the conversion of vitamin D into its active form by cytochrome P450 27B1. Antiviral properties of vitamin D-induced AMPs can shift the polarization of the adaptive immune response from helper T cells (Th)1 to the more regulatory Th2 responses that suppress immune over-reactivity by preventing cytokine storm, which is already demonstrated during the Spanish flu episode. Vitamin D induces antiviral effects by both direct and indirect mechanisms via AMPs, immunomodulation, the interplay between major cellular and viral elements, induction of autophagy and apoptosis, variation of genetic and epigenetic factors. The crosstalk between vitamin D and intracellular signaling pathways may operate as a primary regulatory action on viral gene transcription. VDD may increase the likelihood of infection with enveloped viruses, including retrovirus, hepatitis, and dengue. Global data correlates severe VDD with COVID-19 associated coagulopathy, disrupted immune response and mortality, reduced platelet count, and prolonged prothrombin time, suggesting benefits from supplementation.Key teaching pointsVitamin D induces antiviral effects by direct and indirect mechanisms via AMPs, immunomodulation, induction of autophagy, etc.Epidemiology of VDD partly explains geographical differences in COVID-19 susceptibility, severity, and mortality.Global data correlates severe VDD with COVID-19 associated coagulopathy, disrupted immune response and mortality, reduced platelet count, and prolonged prothrombin time, together suggesting benefits from supplementation.Many clinical trials are underway globally to delineate the role of vitamin D in both prevention and treatment of COVID-19.

The number of children hospitalized with COVID-19 in the United States hit a record high of just over 1,900 on Saturday, as hospitals across the South were stretched to capacity fighting outbreaks caused by the highly transmissible delta variant. The delta variant, which is rapidly spreading among mostly the unvaccinated portion of the US population, has caused hospitalizations to spike in recent weeks, driving up the number of pediatric hospitalizations to 1,902 on Saturday, according to data from the US Department of Health and Human Services. Children currently make up about 2.4% of the nation’s COVID-19 hospitalizations. Kids under 12 are not eligible to receive the vaccine, leaving them more vulnerable to infection from the new, highly transmissible variant. “This is not last year’s COVID. This one is worse and our children are the ones that are going to be affected by it the most,” Sally Goza, former president of the American Academy of Pediatrics, told CNN on Saturday.

The numbers of newly hospitalized COVID-19 patients aged 18-29, 30-39 and 40-49 also hit record highs this week, according to data from the US Centers of Disease Control and Prevention.

The spike in new cases has ramped up tension between conservative state leaders and local districts over whether school children should be required to wear masks as they head back to the classroom this month. School districts in Florida, Texas and Arizona have mandated that masks be worn in schools, defying orders from their Republican state governors that ban districts from imposing such rules. The administration of Florida Gov. Ron DeSantis has threatened to withhold funding from districts that impose mask requirements, and Texas Gov. Greg Abbott is appealing to the state Supreme Court to overturn Dallas County’s mask mandate, the Dallas Morning News reported Friday. A fifth of the nation’s COVID-19 hospitalizations are in Florida, where the number of hospitalized COVID-19 patients hit a record 16,100 on Saturday, according to a Reuters tally. More than 90% of the state’s intensive care beds are filled, according to data from the Department of Health and Human Services. The nation’s largest teachers union, the National Education Association, came out in support of mandatory vaccination for its members this week. NEA President Becky Pringle said Saturday that schools should employ every mitigation strategy, from vaccines to masks, to ensure that students can come back to their classrooms safely this school year, CNBC reported. “Our students under 12 can’t get vaccinated. It’s our responsibility to keep them safe. Keeping them safe means that everyone who can be vaccinated should be vaccinated,” Pringle told CNN.

The US now has an average of about 129,000 new COVID-19 cases per day, a rate that has doubled in a little over two weeks, according to a Reuters tally.

The number of hospitalized COVID-19 patients is at a six-month high, and an average of 600 people are dying each day of COVID-19, double the death rate seen in late July. Arkansas, Florida, Louisiana, Mississippi and Oregon have reported record numbers of COVID-19 hospitalizations this month, according to a Reuters tally,

pushing health-care systems to operate beyond their capacity. “Our hospitals are working to maximize their available staff and beds, including the use of conference rooms and cafeterias,” Florida Hospital Association President Mary Mayhew said in a statement Friday. In Oregon, Gov. Kate Brown said Friday that she was sending 500 National Guard members to assist overwhelmed hospitals, with 1,500 members in total available to help. In Jackson, Mississippi, federal medical workers are assisting understaffed local teams at a 20-bed triage center in the parking garage of the University of Mississippi Medical Center to accommodate the overflow of COVID-19 patients.

Fifteen children and 99 adults were hospitalized with COVID-19 at UMMC as of Saturday morning, the hospital said. More than 77% of those patients were unvaccinated. Nick Note: They are not being forthcoming. The myth that vaccinated people although their infection rate is the same as vaccinated are not dying is just not true. When I extrapolate the data 25% of the people dead were vaccinated. Which is a higher rate than in the past… If you have not received your third booster shot it’s the same in my opinion as if you have not been vaccinated. The fucks at the CDC will soon announce the 3rd booster shots for everyone. I hope it’s not too late for you, We are in deep shit. Your vaccines are useless… The booster shot your 3rd will help… BUT how much remains to be seen. Mask up, vitamin up, isolate and test anyone who comes into your airspace. With testing so easy and cheep test yourself at least once a week. Studies have shown if you get infected the sooner you get treatment the better the outcome… We are down to our last 200 test kits out of a thousand ordered. On sale now while supplies last.

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(Reuters) – The administration of U.S. President Joe Biden is developing a plan to start offering coronavirus booster shots to some Americans as early as this fall, the New York Times reported on Saturday, citing people familiar with the effort. The first boosters are likely to go to nursing home residents and health care workers, followed by other older people who were near the front of the line when vaccinations began late last year, the newspaper reported. Officials envision giving people the same vaccine they originally received. They have discussed starting the effort in October but have not settled on a timetable, the report added.

There is new evidence to show that China locked down all domestic traffic internally by end January 2020 but pushed to open foreign travel till end March. Data from Tom Tom traffic index, a traffic location site that covers 416 cities across 57 countries show that as a result of this strategy, China, intentionally or otherwise, was able to lockdown its cities unknown to the world. While this reduced the spread of the Corona virus within China, China’s aggressive foreign travel policy lead to a virus explosion worldwide. Here is the chronological events of what happened with the requisite traffic data from 10 major cities globally and the statements from Chinese leaders that will help readers reach their own conclusions. The COVID- 19 virus first surfaced in Wuhan in the last week of December. On 31 December 2019 Chinese health officials first reported to WHO that 41 patients in Wuhan had contracted a mysterious pneumonia that was not responding to conventional treatment. As most patients were from the Huanan Seafood Wholesale Market it was closed on the 1st of January. On the 7th of January Chinese scientists identified the virus as a novel Coronavirus later termed as the COVID-19 virus. On the 11th of January the virus claimed its first life in Wuhan city. On 13th January Thailand reported the first case of Coronavirus outside China. On 20th of January Zong Nanshan the scientist named by China to lead the battle against the virus stated ” Now we can say that it is certain that it is a human to human transmission phenomenon”.

On January 22 at a meeting to decide the measures to be taken, WHO was not able warn the world of the severity of COVID-19 apparently because of resistance from Beijing. (WHO referred to it as “divergent views”)

On January 23 Wuhan city was placed under quarantine and two days later the entire Hubei province was locked down. The Chinese state machinery was harnessed to enforce an unprecedented quarantine on 50 million people across 15 cities. In the last week of January domestic flights from Hubei to other parts of China was stopped and restrictions on traffic movement in major cities like Beijing and Shanghai were initiated. This was the time of the Chinese New Year when offices and schools are normally closed and it is also the prime tourism season for the Chinese.

On the 31st January Italy fearing a major outbreak of Coronavirus from hundreds of tourists arriving from China closed all flights to and from China.

China’s vice-minister of foreign affairs Qin Gang met Italy’s ambassador to China Luca Ferrari in Beijing following the flight ban. “Italy’s decision to stop flights without contacting China in advance caused great inconvenience to citizens of both countries. Many Chinese are still stranded in Italy,” the foreign ministry said on its website the following day. The U.S. issued a travel advisory against China travel on the 2nd of February but did not ban all services.

While Chinese authorities limited domestic flights from Wuhan to other Chinese cities like Beijing and Shanghai in an effort to contain the outbreak in January, it urged international carriers to maintain their flying schedules. The Civil Aviation Administration of China stated “In order to meet the needs of passengers in and out of the country and the international transport of supplies during this special period … airlines [are required to] … continue transport to nations that have not imposed travel restrictions.”

China’s assertion that all was well for international travel was supported by the WHO chief Tedros Adhanom Ghebreyesus at the opening of the agency’s Executive Board meet on the 3rd February. He said ” There is no reason for measures that unnecessarily interfere with international travel and trade. We call on all countries to implement decisions that are evidence-based and consistent. WHO stands ready to provide advice to any country that is considering which measures to take,” Foreign Ministry spokesperson Hua Chunying criticised the US advisories saying “The U.S. government hasn’t provided any substantial assistance to us, but it was the first to evacuate personnel from its consulate in Wuhan, the first to suggest partial withdrawal of its embassy staff, and the first to impose a comprehensive travel ban on Chinese travellers”

While China continued to protest against international travel bans it successfully quarantined Wuhan and other affected cities. The total domestic lockdown of Hubei province and the flight ban imposed inside China had immediate effect. As per data from Tom Tom traffic index Wuhan had a traffic density of 60% in January while Shanghai and Beijing had nearly 80% density. After the total lockdown the average traffic density fell to below 10% in Wuhan and Shanghai during February and below 5% in Beijing. While implementing a total domestic lockdown in February, China kept assuring the world that the situation was not serious and fully under control.

China kept on the facade of hiding the severity of the virus attack. It was not till mid March. On the 11th of March WHO belatedly declared COVID-19 a global pandemic. By that time the number of cases globally had grown thirteen fold.

As per WHO website more than 118,000 cases had been reported in 114 countries, and 4,291 people had lost their lives when the global pandemic was declared. That is when the rest of the world started preparing for a suitable response to the pandemic, nearly two months after China. It was only after a telephonic conversation with US President Donald Trump on March 27th that Chinese President Xi Jinping agreed to curb international flights from China. China’s Civil Aviation Administration stated after the discussion “that 90% of international flights would be temporarily suspended. The number of incoming passengers would be cut to 5,000 a day, from 25,000. China has also ordered local airlines to maintain only one route per country, once a week, as of 29th March”. By the end of March COVID-19 had become a full blown global crisis with nearly 10,000 deaths in Italy, Spain and the US and over 5000 in Iran and the UK which was much more than those dead in China. As per data from Tom Tom traffic index the traffic density in Wuhan remained low at around 10% of the normal traffic in March while the major business centres like Beijing and Shanghai which had less than a few thousand cases of COVID-19 and half a dozen deaths showed partial recovery of traffic to around 40%. The rest of the world oblivious of the need for total lockdown took time to react. The traffic remained high at over 60% in major cities like Rome, Milan, Madrid, Paris, London, New York, New Delhi and Mumbai during March. The Tom Tom traffic data index shows that in all other global cities like Rome, Milan, Madrid, Paris, London, New York, New Delhi and Mumbai the traffic density dropped to 10% only in the month of April when most nations went under lockdown.

This was two months after China went in for a domestic lock down and allowed the virus to proliferate to international destinations through human contact.

The traffic density in Beijing and Shanghai rose to over 60% in April showing that the Chinese cities and its economy was back to normal functioning. While China limited its losses to below 5000 by end April 2020, the US had lost 60,000 lives, Italy, Spain, France and UK above 20,000 each and the world saw over 200,000 deaths that was nearly doubling every fortnight.

So though the virus had originated from China which initially infected citizens from 27 nations, because of China’s diabolic international travel policy it spread rapidly to a totally unprepared Europe, mainly Italy and Spain and thereafter to the rest of the world becoming a global pandemic.

So weather the virus was produced in the Wuhan Virology Institute as an exercise of bio-terrorism Nick Bit: I have been told by people who know these kind of things the bat virus was weaponized at the Wuhan bio terror lab and was accidentally released prematurely by careless scientists who are no longer with us.) or simply arrived unintentionally due to bat and pangolin infected blood from its exotic animal markets in Wuhan, China is answerable for the way it allowed the virus to spread. Australia has called for an international investigation into the spread of COVID-19 and all nations of the world including India must back the move. Also it has been suggested that the leadership and the action of WHO chief Tedros Adhanom Ghebreyesus needs to be probed. All nations including India need to support such an investigation for it is better to be safe than sorry.

The Food and Drug Administration on Thursday authorized a third dose of COVID-19 for certain people with compromised immune systems, a narrow move into the realm of booster doses amid a growing debate over their use. The move will allow a third dose of both the Pfizer-BioNTech and Moderna vaccines, and applies to certain immunocompromised people, including those with organ transplants and those “diagnosed with conditions that are considered to have an equivalent level of immunocompromise,” the FDA said. The agency emphasized that the general public does not need a third dose at the moment.Federal health officials officials emphasized the group is small. (Nick Bit: Break it to the masses slowly. The longer they wait to roll out the third booster shot to the masses the more people they kill. It’s OK, they are used to it already. I want to be on the record here… They will EVENTUALLY recommend a third vaccine booster shot for everyone) “The country has entered yet another wave of the COVID-19 pandemic, and the FDA is especially cognizant that immunocompromised people are particularly at risk for severe disease,” said Acting FDA Commissioner Janet Woodcock. “After a thorough review of the available data, the FDA determined that this small, vulnerable group may benefit from a third dose of the Pfizer-BioNTech or Moderna Vaccines.” But health officials have left the door open to third doses, stating that they may be needed eventually. Anthony Fauci, the government’s top infectious disease expert, earlier Thursday said “inevitably” there will be a time when the wider public needs a booster, though now is not the time. “Inevitably, there will be a time when we’ll have to give boosts,” Fauci said on NBC. “What we’re doing, literally, on a weekly and monthly basis is following cohorts of patients to determine if, when and whom should get it.”A broader issuance of booster doses would be controversial given that many people around the world, including health care workers in some countries, are still waiting for their first dose. “Today’s action allows doctors to boost immunity in certain immunocompromised individuals who need extra protection from COVID-19,” Woodcock said. United States Centers for Disease Control and Prevention (CDC) Director Rochelle Walensky said late Thursday night that the number of newly confirmed COVID-19 infections stood at around 113,000 per day over the past week. According to Johns Hopkins University’s tally, the US registered 135,177 new coronavirus cases over the past 24 hours. The number of daily deaths from the disease stood at 342 during the same period. “As we’ve previously stated, other individuals who are fully vaccinated are adequately protected and do not need an additional dose of COVID-19 vaccine at this time. The FDA is actively engaged in a science-based, rigorous process with our federal partners to consider whether an additional dose may be needed in the future.” Nick Note: Bullshit!! I want to be clear here. If your second booster shot is more then 6 months old you need a 3rd booster shot. I got mine you need to get yours… At least mask up, vitamin up, isolate the best you can AND test everyone Who comes into your airspace…

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