FDA panel recommends Pfizer’s COVID-19 vaccine approval

A federal advisory panel on Thursday recommended the emergency use of Pfizer’s COVID-19 vaccine. The Food and Drug Administration is expected to approve the drug, kicking off a massive nationwide operation to get nearly 3 million doses of the vaccine to hospitals and drug stores across the country. “We’ve been working very closely with our state and local partners to make sure they have plans in place to identify providers that are able to receive, store and use the vaccine,” said Dr. Anita Patel, deputy of the CDC’s vaccine task force. The experts voted 17 to 4 in favor of recommending the drug for emergency use for people aged 16 years and older, with one of the members withholding. Health care workers and nursing home residents will be among the first to get the vaccine.

A lot of progress made on stimulus – Mnuchin

US Treasury Secretary Steven Mnuchin has said that senators from both parties are making progress on stimulus talks and more meetings are scheduled for later on Thursday. House Speaker Nancy Pelosi is set to speak later on. The S&P 500 Index has returned to positive territory after trading lower earlier in the day. Mnuchin has said that senators from both parties are making progress on stimulus talks and more meetings are scheduled for later on Thursday. House Speaker Nancy Pelosi is set to speak later on.

Stocks Drop, Bonds Rise Amid Stimulus Stalemate: Markets Wrap

(Bloomberg) — Stocks fell on concern that prospects for a stimulus deal remain elusive amid the most-intense negotiations over a Covid-19 package since Election Day. The S&P 500 also dropped after data showed applications for U.S. unemployment benefits surged last week, topping most estimates. Technology shares continued to underperform, with Facebook Inc. slipping further as the U.S. Federal Trade Commission took a major step toward a possible breakup of the social-media giant by filing an antitrust lawsuit. Airbnb Inc. will start trading Thursday after DoorDash Inc. supercharged investor expectations by almost doubling in its frenzied public debut. Senate Majority Leader Mitch McConnell and House Speaker Nancy Pelosi have given no sign yet that they’re ready to directly engage in negotiations to sort through competing pandemic relief proposals — a step that many lawmakers say will be necessary to complete a deal this month. Meanwhile, House Republican Leader Kevin McCarthy told CNBC that he sees a deal done next week. Elsewhere, the euro rose after policy makers escalated their efforts to shield the region from a possible double-dip recession with another burst of monetary stimulus, while cautioning that it may not use up all the new firepower. The pound fell as negotiations between the U.K. and the European Union were seen on course to end without a trade deal. Surges in Doordash Inc. and C3.ai Inc. on the first day of trading were in keeping with rising speculation for U.S. stock investors, according to Jonthan Krinsky, chief market technician at Bay Crest Partners LLC, who cited the Renaissance IPO and IPOX SPAC indexes. Renaissance Capital LLC’s gauge of initial public offerings rose 32% from a late-October low through Tuesday. In a similar period, IPOX Schuster LLC’s index of current and former blank-check companies climbed 40%. The IPO index fell 3.2% Wednesday even as Doordash gained 86% and C3.ai jumped 120%. The SPAC index rose 0.3%.

More Americans are shoplifting food as aid runs out during the pandemic

The coronavirus recession has been a relentless churn of high unemployment and economic uncertainty. The government stimulus that kept millions of Americans from falling into poverty earlier in the pandemic is long gone, and new aid is still a dot on the horizon after months of congressional inaction. Hunger is chronic, at levels not seen in decades. The result is a growing subset of Americans who are stealing food to survive. Shoplifting is up markedly since the pandemic began in the spring and at higher levels than in past economic downturns, according to interviews with more than a dozen retailers, security experts and police departments across the country. But what’s distinctive about this trend, experts say, is what’s being taken – more staples like bread, pasta and baby formula. “We’re seeing an increase in low-impact crimes,” said Jeff Zisner, chief executive of workplace security firm Aegis. “It’s not a whole lot of people going in, grabbing TVs and running out the front door. It’s a very different kind of crime – it’s people stealing consumables and items associated with children and babies.” With Americans being advised to brace for a difficult winter amid skyrocketing coronavirus infection rates and the economic recovery nearly stalled, the near-term outlook is grim. More than 20 million Americans are on some form of unemployment assistance, and 12 million will run out of benefits the day after Christmas unless new relief materializes. Though lawmakers have made progress this week on a $908 billion bill, details are still being worked out, congressional aides said. Meanwhile, an estimated 54 million Americans will struggle with hunger this year, a 45% increase from 2019, according to the U.S. Department of Agriculture. With food aid programs like SNAP and WIC being reduced, and other federal assistance on the brink of expiration, food banks and pantries are being inundated, reporting hours-long waits and lines that stretch into the thousands. Several federal food programs that have provided billions of dollars in fresh produce, dairy and meat to U.S. food banks also are set to expire at the end of the year. The largest among them, the Farmers to Families Food Box, has provided more than 120 million food boxes during the pandemic and is already running out of funding in many parts of the country. With the United States now registering more than 150,000 new cases a day, some communities are reintroducing restrictions in an effort to contain the virus. Most of California is now under strict stay-at-home orders, for example, while states including Nevada, Maryland and Pennsylvania have issued new indoor occupancy limits. Such orders tend to hit already vulnerable workers in low-wage service jobs in restaurants, retail and bars the hardest. Nearly 26 million adults – or 1 in 8 Americans – reported not having enough food to eat as of mid-November, according to the latest data from the Census Bureau. That figure has climbed steadily during the pandemic, and has hit record highs since the government agency began collecting such data in 1998.

Ivermectin And Doxycycline To Treat Mild/Moderate COVID-19: Randomized, Double Blinded, Placebo Ctrl

https://youtu.be/5MNsM-ZhRS4

This video we will discuss and review a trial from ClinicalTrials.gov that have reported their results, but not published them. It is a randomized, double blinded, placebo control trial out of Bangladesh comparing treatment with Ivermectin and Doxycycline with standard care (tylenol, vitamin D, steroids as needed, oxygen as needed, etc) versus standard care alone. Their reported results were quite impressive. They reported increased clinical improvement at 7 days, decreased clinical deterioration at 30 days, and decreased viral loads at 14 days in those who received IVM and Doxy! Were there any adverse effects? Check out the video for all the details! Link to the study below:

https://clinicaltrials.gov/ct2/show/r…

Called a Miracle Anti Viral Ivermectin

‘Generic Drug Repurposing for COVID-19” The Israeli Perspective’: Tel Aviv University’s Spark program recently hosted a webinar titled “Generic Drug Repurposing for COVID-19: The Israeli Perspective.” In collaboration with the MedInsight Institute, presenters included Professor Alex Jadad, Faculty of Medicine and School of Public Health, University of Toronto, Canada; Moshe Rogosnitzky, Executive Director, MedInsight Research Institute from both New York and Israel; professor Yaakov Nahmias, Director for the Center of Bio engineering, the Hebrew University of Jerusalem; and Professor Eli Schwartz with Sheba Medical Center, Tel Aviv University, #Israel, who presented the “Sheba #Ivermectin Project (SIP).” Establishing a movement in Israel to consider the repurposing of generic drugs for purposes of economically and forcefully targeting #COVID-19, the drugs discussed in this presentation included Ivermectin, are potentially safe, effective and widely accessible. The organizers of this event are clear for the world to hear: “Of the 9,000 currently approved drugs that exist globally, the potential for overcoming COVID-19 certainly exists.” https://trialsitenews.com/generic-dru… The FLCCC Alliance press conference from Houston, Texas: Some Highlights from the press conference starring the Frontline COVID19 Critical Care Alliance from Houston, Texas to discuss emerging evidence for economical and widely available therapeutic possible options for treating early-stage COVID-19 cases. See the whole press conference here: https://www.youtube.com/watch?v=4V3yx… Great Plains Health Severe COVID-19 Patients Benefit from RLF-100: Recently showcased on local media, North Platte Nebraska’s Great Plains Health (GPH) has treated at least 20 patients with Aviptadil (RLF-100), an investigational product recently submitted for emergency use authorization in late September. One of those surviving patients, Mark Cardenas, went on air to share his experience and thanks for the access. It literally may have saved his life. Produced by a Swiss company called Relief Therapeutics, Great Plains Health infectious disease physician Eduardo Freitas heard about the drug via a network of other physicians. It was through that network that Dr. Freitas was able to secure a communication channel with U.S and Israel-based NeuroRx, the biotechnology company that co develops the drug for commercialization. TrialSite has reported on a few situations in Texas where patients with severe COVID-19 experienced marked improvement thanks to access to the drug opened up by the U.S. Food and Drug Administration via clinical trials and Expanded Access Protocol. It is through the latter that GPH was able to offer the investigational product to select patients facing severe COVID-19 conditions. https://trialsitenews.com/great-plain…

Ivermectin Works For COVID-19 – LATEST STUDIES

https://youtu.be/V4fEBK1inj4

Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019

Link Here: https://doi.org/10.1016/j.chest.2020.10.009

Original in-vitro study about Ivermectin https://www.ncbi.nlm.nih.gov/pmc/arti…

A study from bangladesh found that Ivermectin + Doxyclyclin significantly reduces mortality and morbidity in COVID-19 patients. https://clinicaltrials.gov/ct2/show/s…

A systemic review of the antiviral activity of Ivermectin https://www.nature.com/articles/s4142… https://journal.chestnet.org/article/… PDF for the above study after it was accepted

https://journal.chestnet.org/article/… Pre-print of the above study https://www.medrxiv.org/content/10.11…

A search of various Ivermectin studies for your reading pleasure https://clinicaltrials.gov/ct2/result…

Iota carrageenan and Ivermectin oral drops https://clinicaltrials.gov/ct2/show/r…

Here is a index of the Clinical studies I have reviewed their are 44 of what i call suppressed studies. Think about it big Pharah has been given world wide 250 billion for the various vaccines. The medicines in the studies cost pennies a dose. Big Pharma wins the and over 2 million people dead have lost. they did not have to die:

https://clinicaltrials.gov/ct2/results?cond=Covid19&term=ivermectin&cntry&state&city&dist

 

 

 

Breakthrough Ivermectin used to treat COVID-19

https://youtu.be/Tq8SXOBy-4w

Pierre Kory, M.D., Associate Professor of Medicine at St. Luke’s Aurora Medical Center, delivers passionate testimony during the Senate Homeland Security and Governmental Affairs Committee hearing on “Early Outpatient Treatment: An Essential Part of a COVID-19 Solution, Part II.”

  • Ivermectin has been trialled in treating the coronavirus SARS-CoV-2, which is the virus that causes COVID-19.
  • The trials so far have shown ivermectin reduces the number of cell-associated viral RNA by 99.8 % in 24 hours. This was an in vitro study which means they were testing cells in a laboratory and not in a living organism.
  • Studies are now needed to be done on ivermectin on people or animals to see how well ivermectin works against COVID-19. This is in vivo testing.
  • Ivermectin is currently a FDA approved medicine for treatment of intestinal worms, Strongyloides stercoralis and Onchocerca volvulus. It has been established as safe for human use.

What is Ivermectin?

  • Ivermectin is currently used to treat parasite infections such as intestinal worms, lice and mites.
  • Recently ivermectin has also been studied to treat a range of viruses.

How does Ivermectin work on COVID-19?

  • For the SARS-CoV-2 virus to make you sick, it has to first infect your cells.
  • Then while inside the cell, the virus makes heaps of copies of itself, so it can spread around your body.
  • The virus also has ways of reducing the way your body fights the infection.
  • During the infection of the cell, some viral proteins go into the cell nucleus, and from here they can decrease the body’s ability to fight the virus, which means the infection can get worse.
  • To get into the nucleus the viral proteins need to bind a cargo transporter which lets them in.
  • Ivermectin can block the cargo transporter, so the viral proteins can’t get into the nucleus. This is how the scientists believe Ivermectin works against SARS-CoV-2 virus.
  • By taking Ivermectin, it means the body can fight the infection like normal, because its antiviral response hasn’t been reduced by the viral proteins.

Is Ivermectin an approved medicine by the FDA?

Ivermectin tablets (Stromectol) is an approved medicine by the FDA for use in intestinal worms Strongyloides stercoralis and Onchocerca volvulus

As Ivermectin is already a FDA approved medicine we already know that it has been established as safe for human use.

Bottom line

  • Clinical trials in the laboratory (in vitro) on ivermectin show that ivermectin reduces the number of cell-associated viral RNA by 99.8 % in 24 hours, for the SARS-CoV-2 which is the virus that causes COVID-19.
  • Ivermectin is already a FDA approved medicine for some types of intestinal worms
  • It is known that ivermectin has a good safety profile.

Dow Turns Red as Tech Slips, Stimulus Talks Stall

https://youtu.be/GyDRe_vuKGk

(Dec. 9) Treasury Secretary Steven Mnuchin made a surprise re-entry into talks on a 2020 pandemic-relief package with a $916 billion proposal that opened a potential new path to a year-end deal despite objections from Democrats over elements of the plan. After largely leaving the task to Senate Majority Leader Mitch McConnell since Election Day, Mnuchin pitched a $916 billion stimulus plan to House Speaker Nancy Pelosi in a Tuesday afternoon telephone call, more than a week after she and Senate Democratic leader Chuck Schumer retreated from their previous insistence on a $2.4 trillion bill. Mnuchin’s offer was a joint proposal supported by McConnell and House Republican leader Kevin McCarthy, who called it “a great offer.” Mnuchin said he had conferred with President Donald Trump, whose support will be needed to get any deal through the Republican-controlled Senate. Pelosi and Schumer said in a joint statement that it marked “progress” because it brought McConnell closer to the $908 billion framework unveiled last week by a group of Democratic and Republican lawmakers. But they said its omission of supplementary jobless benefits was “unacceptable,” and backed the continuing bipartisan effort at crafting a compromise. The Mnuchin plan differs in important ways from the alternative that Pelosi and Schumer endorsed as a basis for fresh talks. It includes $600 stimulus payments to individuals, which could win support from both Republicans and Democrats, but it pays for that in part through cutting the bipartisan proposal for $300 a week in supplemental unemployment aid. It also includes what Mnuchin described as “robust” protections for employers from Covid-19-related lawsuits, something Democrats have opposed. Negotiators on the bipartisan plan had been working on a proposed moratorium that offered potential for a compromise. It does have $160 billion in aid for state and local authorities, much the same as the bipartisan plan. Mnuchin’s pitch ties state and local aid together with liability protections — the two key roadblocks to a deal so far — so they can either be removed or stay in together, according to McCarthy. McConnell earlier Tuesday had floated the idea of setting aside those two issues, but Democratic leaders quickly rejected dropping aid to states and localities. Meantime, the bipartisan group continued their own negotiations. Their work over the weekend and early this week on turning the plan into legislative language had slowed amid the persistent disagreements over state and local aid and the Covid-19 liability protections that McConnell in particular has championed. The Mnuchin offer, which was made to Pelosi in the 5 p.m. call, was essentially a joint proposal from the White House, McConnell and McCarthy. That marks a turnaround for McConnell, who since the election has stuck with pitching a smaller-scale effort that Democrats had previously blocked. That focused mainly on renewed Paycheck Protection Program help for small businesses — something that’s in both Mnuchin’s and the bipartisan plan — education aid and funding for vaccine distribution and other Covid-19 initiatives. Asked about Mnuchin’s plan, a spokesman for McConnell said the leader had no further remarks beyond his statement earlier Tuesday. But a person familiar with the matter said it represents a joint proposal supported by Mnuchin, McCarthy and McConnell. Lawmakers from both parties have said that any Covid-19 relief deal would be attached to a government-spending bill. Current stopgap funding for federal agencies runs out Friday night, and the House plans to vote Wednesday on a new seven-day continuing resolution to avert a shutdown. The Senate aims to take that up thereafter. That would give another week for talks to continue on both the stimulus front and on an omnibus spending bill to fund the government into 2021.

First signs of Thanksgiving COVID-19 wave emerge

 

The first signs of a post-Thanksgiving surge in coronavirus cases are beginning to show up in data released by states across the country in a troubling prelude of what may become the deadliest month of the pandemic so far. Those hints of an uptick in case counts come as the country faces an already substantial wave of infections that began in the Upper Midwest and spread to every corner of the map as summer turned to fall and the weather cooled. The United States has averaged nearly 200,000 new confirmed cases a day over the last week, according to The Covid Tracking Project, run by a group of independent researchers. More than 2,200 people a day have died on an average during that period. The number of patients being treated in hospitals has crested 102,000, the highest levels of the pandemic. The country still lacks a national testing strategy that public health experts say is essential to bringing the pandemic under control. President Trump’s remarks about the virus have become few and far between, even as he continues to hold in-person events where attendees are mostly maskless. The White House held a vaccine summit on Tuesday, though representatives from the two companies that have produced the earliest vaccines were not present. There are some hopeful signs that the third wave is ebbing in parts of the Midwest. The number of newly confirmed cases has declined for two straight weeks in 10 states, including hard-hit Wisconsin, Iowa, Michigan and New Mexico. But new data shows other states experiencing substantial increases. In Alabama, where authorities reported about 14,000 new cases a week through middle and late November, case counts jumped to more than 22,000 in the first week of December. Georgia’s case counts rose in early December by about 50 percent from its November figures. Florida cases spiked to 65,000 last week, a substantial increase over its averages last month. “At this point, we could be just picking up the beginning of the Thanksgiving surge, but surely in the following week we’re going to see it,” said Michael Osterholm, director of the Center for Infectious Disease Research and Prevention at the University of Minnesota. “We’re slingshotting this surge of cases into the holiday season in a way that is truly dangerous.” Cases have risen over the last week in 38 states and the District of Columbia. In the summer wave, the virus was spreading fastest in Arizona, where at its peak 380 residents per 100,000 were becoming infected every week; now, 35 states have per capita infection rates higher than that.Several states have already opened field hospitals to handle the new surge. In California, Los Angeles County and the Bay Area are reimposing harsh lockdowns to try to contain the spread. In Wyoming, Gov. Mark Gordon (R) issued his first statewide mask mandate. In another troubling sign, the percentage of patients diagnosed with COVID-19 who are admitted to hospitals is declining. That suggests that some medical facilities, concerned about space and staff levels, are sending home some people who might have been admitted earlier in the year, compromising their ability to monitor a very sick person and intervene immediately if necessary. There is hope that highly effective vaccines created by Pfizer and the German pharmaceutical firm BioNTech and by Moderna will win approval from federal regulators in the coming days, but distribution challenges mean it will still be months until the bulk of Americans get access to either.

Until then, epidemiologists and public health experts say they remain concerned that the number of cases will continue to spike, especially if Americans treat the winter holiday season as casually as they did Thanksgiving, when millions got on planes or drove to be with friends and family outside their immediate households.

“The United States is going to kind of muddle through this until there’s a vaccine,” said Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security. “It’s becoming increasingly unlikely that we will gain control of this until we have a vaccine.” In that dangerous interregnum between vaccine approval and widespread deployment, millions of Americans are at risk of infection and thousands will die. Projections from the Institute for Health Metrics and Evaluation (IHME) at the University of Washington School of Medicine estimate another 265,000 people will die in the United States by April 1. “Mass scale-up of vaccination in 2021 means we have a path back to normal life, but there are still a few rough months ahead,” IHME Director Christopher Murray said in a statement. And those estimates cover only deaths from COVID-19. Health experts are just as worried about deaths tangentially related to the pandemic. If hospitals are overrun by coronavirus patients, those who need immediate care for other health crises — heart attacks, strokes or injuries — may find that care is not as available as it might be under normal circumstances.

We’re now worrying about hospital capacity in December,” Adalja said. “It’s not just the direct deaths.”

There is already evidence that the number of drug overdoses has increased during the pandemic. The number of cancer screenings has declined markedly, raising concerns that early-stage cancers will go undetected until they become far more deadly. The pandemic fatigue that has settled on a nation exhausted by months of lockdowns, social distancing and economic pain is a vexing problem for public health officials who need Americans to hang on now that an end is in sight. Some say the messages politicians and public health officials send need to be tougher than it has been. “I wish every person could spend 30 minutes in the corner of an ICU. They would have a very different sense of reality,” Osterholm said. “When people start dying in emergency rooms because they can’t get a bed, maybe that’s when Americans will get a different sense of reality.”