AstraZeneca’s vaccine trial still on hold in US – company

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AstraZeneca’s COVID-19 vaccine trails remain on hold in the United States, despite resuming in countries such as the United Kingdom, India, Brazil, and South Africa. On September 19, the New York Times reported on the recently published document by AstraZeneca describing protocols of how the trials are being conducted by the pharmaceutical company. The blueprint came amid increasing pressure from the scientific community who demanded AstraZeneca to be more transparent about its vaccine trials. As per the report, the United States Food and Drug Administration (FDA), which is the top-most authority that clears or holds vaccines, did not allow AstraZeneca to resume trials. The National Institutes of Health, an agency of the US Health Department said that it is a “standard procedure” to pause the trials as they are not sure whether the illness in volunteers was coincidental or tied to the vaccine. In the study published on Saturday, AstraZeneca, however, did not reveal many details about the illness in volunteers This comes after the company paused the trials earlier this month as two of the volunteers developed illnesses. Clinical trials of the vaccine, AZD1222, resumed in the UK following confirmation by the Medicines Health Regulatory Authority (MHRA) that it was safe to do so. On September 12, AstraZeneca had said that it cannot disclose further medical information on the trials. AZD1222, which was being dubbed as the front-runner in the vaccine race by WHO, has been developed by the University of Oxford in partnership with AstraZeneca.

The vaccine uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein.

After vaccination, the surface spike protein is produced, priming the immune system to attack the COVID-19 virus if it later infects the body

U.S. Covid-19 death toll surpasses 200,000

The first reported death in the U.S. from Covid-19 was on February 29th. Now, 7 months later, it’s hard to fathom that we have more than 200,000 reported deaths and over 6 million cases.

But the harsh reality is this: as the U.S. marks the passing of 200,000 lives based on reporting earlier today by NBC News, Covid-19 continues to kill hundreds of Americans daily— 937 yesterday, based on data from Johns Hopkins.

In fact, when Dr. Deborah Birx, coordinator of the White House coronavirus task force, made a prediction on the White House lawn on March 30th, SARS-CoV-2, the virus responsible for Covid-19, had killed less than 3,000 people. “If we do things together, well almost perfectly, we can get in the range of 100,000-2000,000 fatalities,” Birx offered, as she explained to Savannah Guthrie on the Today Show. “We don’t even want to see that,”, she added. But her prediction came true today as the number of deaths from Covid-19 exceeded 200,000. “It’s not surprising that the U.S. has crossed the 200,000 death mark as, over six months into the pandemic and nine months since the emergence of the virus, many parts of the U.S. are still incapable of testing, tracing, and isolating, said Amesh Adalja, M.D., an infectious disease physician, and Senior Scholar, Johns Hopkins Center for Health Security. “The inability for individuals to rapidly test, know their status, and make informed decisions about their activities will continue to lead to undetected chains of transmission that eventually land on vulnerable people, so I expect the death count to continue to increase.” What’s abundantly clear is that this could have gone much differently, as Adalja clearly explains. And a robust national plan that focuses on rapid tests, contact tracing and isolation is still not in place. What’s even more concerning is that tens of thousands of people could have been saved if we had a cohesive national strategy, an earlier national lockdown, and a unified strategy that took the lives of all Americans into consideration. This could have even included a nationwide universal masking policy along with a national strategy for distribution of PPE, instead of individual states “going it alone”. Maybe part of the plan could also have included distributing 650 million masks nationwide—five reusable face masks for every American household—that were supposed to be delivered through the United States Postal Service (USPS) back in April, according to a Washington Post report yesterday, but unfortunately never happened. The documents even included a draft of a press release from the USPS to distribute the 650 million masks throughout the country. But thanks to the watchdog, American Oversight, which obtained close to 10,000 pages of federal emails and documents via the Freedom of Information Act (FOIA), we now know that Americans never received the masks because the plan was never implemented. It turns out that the White House Domestic Policy Council and the Office of the Vice President thought that sending masks to households might create “concern or panic.” Rather than creating “concern”, shipping masks could have provided protection and security for a high percentage of Americans for a virus that may be transmitted asymptomatically and is airborne, based on current research. What’s clear is this: the U.S. is the current global leader in total cases and total deaths, according to data from Johns Hopkins CSSE. Yet close to 3 million people will “most likely” die of Covid-19 globally by the end of the year if countries don’t place a greater focus on wearing masks and tightening restrictions on social distancing, according to data from the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. But a second wave or surge in the number of new cases in the coming fall and winter, along with progressive fatigue with social distancing and wearing masks could lead to more than 415,000 deaths in the U.S. by January 1, the IHME has projected. Certainly there has been concern about the accuracy of IHME modeling early in the pandemic, with underestimation of the number of deaths nationwide, as well as an inaccurate projected death toll made in April for August (60, 415). These projections are just that—projections. But changes in adherence to social distancing and wearing masks can make a significant difference in modeling and estimates of death. That said, we are still on the wrong trajectory. According to data from Johns Hopkins CSSE, there were 49,522 new cases and 937 deaths in the U.S yesterday. Until a viable and thoroughly tested vaccine is available, we must adhere to other public health approaches that are currently available: universal masking along with strict adherence to social distancing.

London police breaks up anti-coronavirus protests

London’s police on Saturday tried to break up a protest by more than a thousand people opposed to lockdown measures aimed at slowing the spread of coronavirus.

Demonstrators had gathered in Trafalgar Square in central London carrying banners saying “Freedom Not Fear” and “Scam” and chanting at police: “Choose your side”.

Shortly before 1400 GMT police ordered protesters to leave, saying the demonstration was putting other members of the public at risk. “This, coupled with pockets of hostility and outbreaks of violence towards officers, means we will now be taking enforcement action to disperse those who remain in the area,” London’s Metropolitan Police said in a statement. A Reuters witness said several hundred people remained in the square at 1500 GMT as police tried to clear the area. A police spokesman had no immediate information on whether there had been any arrests. Under laws to slow the spread of COVID-19, people in England are not allowed to gather in groups of more than six. There are exemptions for political protests, but only if organizers follow guidelines to reduce the risk of the disease spreading. Organizers of previous anti-lockdown protests have been fined up to 10,000 pounds ($12,914).

Britain has suffered Europe’s highest death toll from COVID-19, with more than 41,000 deaths on the government’s preferred measure, and tests for the disease have not kept up with demand since English schools reopened this month.

Prime Minister Boris Johnson is currently considering whether to reimpose some lockdown restrictions across England. Rising case numbers in parts of northern England have already led to local restrictions on people inviting friends to their homes, and reduced pub and restaurant opening hours.

France reports highest number of new COVID-19 cases in a day

PARIS (Reuters) – France registered a record 10,593 new confirmed coronavirus in the past 24 hours, health ministry data showed on Thursday, the country’s highest single-day count since the pandemic began. The rise followed a government decision to make COVID-19 tests free, leading to a surge in testing and an increase in infection rates. The previous high in 24 hours in France was 10,561 new cases, recorded on Sept. 12. The seven-day moving average of new cases – which smoothes out irregularities – rose to a high of nearly 8,800. The ministry reported that the cumulative number of cases had risen to 415,481, and the death toll had risen by 50 to 31,095, the second-highest number of new deaths in a day in two months. The government’s decision to make COVID-19 testing free has resulted in long queues at testing centres in cities and testing has increased six-fold since the peak of the first coronavirus wave. About 1.2 million tests were carried out last week, the health minister said. Data show 5.4% of tests were positive. Doctors say many tests are pointless as some people who have no symptoms, or have had no contact with people with confirmed cases, take multiple tests. “To get tested three times a week is totally delirious. Anyone can show up and say they have symptoms,” Jean-Jacques Zambrowski, a doctor and health policy lecturer at Paris Descartes university, said on BFM TV. French television showed scenes of chaos at testing centres in big cities, with people waiting hours and jostling in queues. Hundreds of workers at laboratories went on strike on Thursday over poor working conditions as the testing system buckles under the demand. The number of people being treated in hospital for COVID-19 rose by 25 to 5,844, the 19th consecutive daily increase after a low of 4,530 at the end of August, down from a mid-April high of over 32,000.

Airlines Make Final Plea for Aid to Avoid Job Losses

 

Top executives at major airlines including American Airlines Group Inc., Southwest Airlines Co. and United Airlines Holdings Inc. met Thursday with White House chief of staff Mark Meadows as the companies and their employees make a final push for more job-saving government aid. Airlines agreed not to furlough or lay off employees through the end of September in exchange for $25 billion as part of a broad pandemic relief package last spring. They hoped the funds would see them through the worst of the crisis, but six months later, travel demand is still hovering at around 30% of last year’s levels and airlines expect recovery to be rocky and slow. The restrictions of the first round of aid expire at the end of the month. Unless they receive another infusion of cash, airlines have said they would furlough tens of thousands of workers starting Oct. 1. President Trump and lawmakers in both parties have said they support providing another $25 billion in aid to airlines so they can keep paying all their workers through next March. But Congress has been unable to come to terms on a broader relief package that could include the airline funds, and time is running out. “We remain hopeful for an outcome that spares thousands of our colleagues and their families from what we regard as an avoidable fate,” American Chief Executive Doug Parker and the leaders of the airline’s unions wrote Wednesday in a joint letter to the White House, the Treasury, and Congressional leaders. American has said that some 19,000 of its employees will lose their jobs through furloughs and layoffs Oct. 1 without additional aid. Airline executives and industry lobbyists have grown more pessimistic as Democrats and Republicans in Congress have remained at an impasse over basic questions like the overall size of the next relief package. Mr. Meadows has said previously that the administration was looking into executive orders that could assist the industry, but details have been murky.More recently, there have been signs of movement. Mr. Trump, who has largely remained on the sidelines during the latest discussions, said in a tweet Wednesday that Republicans should seek a more expensive aid package — something that could bring the two sides closer to an agreement. Airlines and labor unions are continuing to plan for the possibility that no further aid is coming. Southwest Airlines has said enough employees agreed to depart on their own that it won’t need to furlough any this year. Delta Air Lines Inc. said this week that it had been able to save enough through voluntary departures, reductions in workers’ hours and other measures that it won’t cut any flight attendants, mechanics, or other front-line workers, with the exception of pilots. Currently the airline is planning to furlough over 1,900 pilots, though the company and the union are still discussing measures that could mitigate that figure. United Airlines pilots are voting on whether to accept reductions in their work schedules, which translates into lower pay, in exchange for a guarantee that all their jobs would be safe until at least June. Union leaders endorsed the proposal Wednesday and members will vote at the end of this month, just days before the first swath of furloughs is due to go into effect. “Hundreds of thousands of airline workers need the CARES Act extension, but with pilot furloughs just weeks away, we can’t wait,” Capt. Todd Insler, chairman of United’s pilots union, said in a statement.

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Bank of England eyes sub-zero rates in face of virus, Brexit

LONDON — The Bank of England indicated Thursday that it could cut interest rates below zero for the first time in its 326-year history as it tries to shore up a U.K. economic recovery that is facing the dual headwinds of the coronavirus and Brexit. After unanimously deciding to maintain the bank’s main interest rate at the record low of 0.1%, the nine-member rate-setting Monetary Policy Committee said it had discussed its “policy toolkit, and the effectiveness of negative policy rates in particular.” In minutes accompanying the decision, the rate-setters said a recent wave of virus infections has “the potential to weigh further on economic activity, albeit probably on a lesser scale than seen earlier in the year.” Though the committee noted that recent economic data have been a “little stronger than expected” at its last meeting in early August, it said it is unclear what that says about the future “given the risks.” One clear concern relates to whether Britain, like others in Europe, will reimpose broad restrictions on businesses and public life after the recent flare-up in virus infections across the region. Already social gatherings are being restricted and certain areas of the U.K. are seeing localized lockdowns. The British economy suffered one of the deepest recessions in the world this year when many sectors were effectively mothballed to help contain the pandemic. Though it recouped some ground in the summer as lockdown restrictions were eased, the economy was still around 12% smaller at the end of July than it was in February, when the pandemic started in Europe. The other major risk facing the U.K. economy relates to the post-Brexit trade discussions between the U.K. and the EU following a worsening in relations. If the talks collapse, tariffs and other impediments to trade will be imposed by both sides at the start of 2021, a development that would hurt the U.K. more. The U.K. left the EU on Jan. 31, but is in a transition period that effectively sees it benefit from the bloc’s tariff-free trade until the end of the year while the future relationship is negotiated. With the outlook so murky, the bank was not expected to provide more stimulus on Thursday. Since the pandemic started, it has cut its main rate to a record low and boosted its bond-buying program to oil the financial market’s wheels and keep borrowing affordable. The policymaking panel said Thursday it could take further action on borrowing costs after revealing it had been briefed on how to effectively implement negative interest rates, which would seek to encourage banks to lend rather than hoard their cash. The central bank will further discussions the potential use of negative rates during the fourth quarter. Though that doesn’t necessarily mean a rate cut is likely this fall, it’s a clear signal that the bank could enact further stimulus measures. “While the Bank is clearly exploring the possibility of using negative rates as a potential tool, we doubt it will go down that path anytime soon — at any rate, not in November,” said Kallum Pickering, senior economist at Berenberg Bank. Still, financial markets interpreted the announcement as increasing the likelihood of negative rates next year, potentially in the event of the U.K. and the EU failing to agree on a trade deal. The pound fell 0.7% to $1.2884. Most economists think the bank will boost its bond-buying stimulus program in November. By then, unemployment across the U.K. is expected to be rising sharply as a government salary support program will have come to an end. The Job Retention Scheme, under which the government pays the bulk of the salaries of workers that firms keep on rather than fire, has kept a lid on unemployment. However, it ends on Oct. 31, a change that most economists think will more or less double the U.K.’s unemployment to around 8% from 4.1% at present.

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France reports 10,593 new COVID-19 cases

PARIS (Reuters) – France registered a record 10,593 new confirmed coronavirus in the past 24 hours, health ministry data showed on Thursday, the country’s highest single-day count since the pandemic began. The rise followed a government decision to make COVID-19 tests free, leading to a surge in testing and an increase in infection rates.The previous high in 24 hours in France was 10,561 new cases, recorded on Sept. 12. The seven-day moving average of new cases – which smoothes out irregularities – rose to a high of nearly 8,800. The ministry reported that the cumulative number of cases had risen to 415,481, and the death toll had risen by 50 to 31,095, the second-highest number of new deaths in a day in two months. The government’s decision to make COVID-19 testing free has resulted in long queues at testing centres in cities and testing has increased six-fold since the peak of the first coronavirus wave. About 1.2 million tests were carried out last week, the health minister said. Data show 5.4% of tests were positive. Doctors say many tests are pointless as some people who have no symptoms, or have had no contact with people with confirmed cases, take multiple tests. “To get tested three times a week is totally delirious. Anyone can show up and say they have symptoms,” Jean-Jacques Zambrowski, a doctor and health policy lecturer at Paris Descartes university, said on BFM TV. French television showed scenes of chaos at testing centres in big cities, with people waiting hours and jostling in queues. Hundreds of workers at laboratories went on strike on Thursday over poor working conditions as the testing system buckles under the demand.The number of people being treated in hospital for COVID-19 rose by 25 to 5,844, the 19th consecutive daily increase after a low of 4,530 at the end of August, down from a mid-April high of over 32,000.

Leaked FEMA Memo Reveals 17 Percent Jump in U.S. COVID Deaths Last Week

An internal memo from the Federal Emergency Management Agency obtained by ABC News on Wednesday night showed that the current national trend in new cases is only slightly down while the trend in new deaths is way up. There were 261,204 new cases of COVID-19 confirmed in the United States during the period of Sept. 9-15, a 0.7% decrease from the previous week. Meanwhile, 5,906 coronavirus-related deaths were recorded during that same period, a 16.6% increase compared with the seven days prior, according to the FEMA memo. The national positivity rate for COVID-19 tests currently stands at 4.4%, a 0.1% decrease over the past week, according to the memo. There were 36,782 new cases of COVID-19 identified in the United States on Wednesday, according to a real-time count kept by Johns Hopkins University. Wednesday’s tally is far below the country’s record set on July 16, when there were 77,255 new cases in a 24-hour-reporting period. An additional 977 coronavirus-related fatalities were also recorded Wednesday, down from a peak of 2,666 new fatalities reported on April 17.
By May 20, all U.S. states had begun lifting stay-at-home orders and other restrictions put in place to curb the spread of the novel coronavirus. The day-to-day increase in the country’s cases then hovered around 20,000 for a couple of weeks before shooting back up and crossing 70,000 for the first time in mid-July. The daily tally of new cases has gradually come down since then.

Coronavirus cases in US up by 74,667 in a day

United States COVID-19 Cases and Deaths by State

Reported to the CDC since January 21, 2020

USA
6,571,867
TOTAL CASES
+34,240 Cases since yesterday
CDC | Updated: Sep 16 2020 12:16PM
USA
195,053
TOTAL DEATHS
+961 Deaths since yesterday
CDC | Updated: Sep 16 2020 12:16PM
USA
261,204
Cases in Last 7 Days
CDC | Updated: Sep 16 2020 12:16PM
Total Cases by State/Territory
State/Territory Total Cases Confirmed Probable
California
760,013
N/A
N/A
Texas
668,746
N/A
N/A
Florida
660,946
N/A
N/A
Georgia
296,833
N/A
N/A
Illinois
266,305
264,210
2,095
New York City*
239,547
234,225
5,322
Arizona
209,209
207,220
1,989
New York*
207,341
N/A
N/A
New Jersey
197,404
N/A
N/A
North Carolina
186,887
N/A
N/A
Tennessee
175,231
169,893
5,338
Louisiana
159,253
N/A
N/A
Pennsylvania
146,214
141,950
4,264
Alabama
140,160
126,813
13,347
Ohio
139,485
132,118
7,367
Virginia
136,359
129,963
6,396
South Carolina
133,470
130,917
2,553
Massachusetts
133,321
123,425
9,896
Michigan
124,969
113,183
11,786
Maryland
117,888
N/A
N/A
Indiana
107,229
N/A
N/A
Missouri
105,396
N/A
N/A
Wisconsin
96,938
91,304
5,634
Mississippi
91,234
85,384
5,850
Minnesota
85,351
N/A
N/A
Washington
80,465
N/A
N/A
Oklahoma
78,299
71,314
6,985
Iowa
75,389
N/A
N/A
Nevada
74,008
N/A
N/A
Arkansas
71,357
N/A
N/A
Colorado
62,099
57,805
4,294
Utah
60,005
59,511
494
Kentucky
58,000
51,862
6,138
Connecticut
55,031
52,767
2,264
Kansas
49,899
48,139
1,760
Nebraska
38,970
N/A
N/A
Puerto Rico
38,284
18,252
20,032
Idaho
35,810
32,947
2,863
Oregon
29,662
28,223
1,439
New Mexico
26,923
N/A
N/A
Rhode Island
23,250
N/A
N/A
Delaware
19,137
18,138
999
South Dakota
16,994
N/A
N/A
North Dakota
16,333
N/A
N/A
District of Columbia
14,687
N/A
N/A
West Virginia
12,976
12,672
304
Hawaii
10,834
N/A
N/A
Montana
9,244
9,244
0
New Hampshire
7,748
N/A
N/A
Alaska
6,395
N/A
N/A
Maine
4,941
4,434
507
Wyoming
4,438
3,762
676
Guam
1,966
N/A
N/A
Vermont
1,701
N/A
N/A
Virgin Islands
1,232
N/A
N/A
Northern Mariana Islands
61
61
0
American Samoa
0
N/A
N/A
Federated States of Micronesia
0
0
0
Palau
0
N/A
N/A
Republic of Marshall Islands
0
0
0
CDC | Updated: Sep 16 2020 12:16PM

AMERICA: China and Russia Are Plotting to Destroy Us

It seems clear now that Covid-19 will take a place in world history, a seismic event of the twenty-first century whose effects will only be fully understood over many years, even decades. What also seems clear is that the United States-China relationship will change — indeed, must change. The question is how, and along what lines. Among Americans, anger at China runs high. American voters may, in the short term, choose to blame the Trump administration at the polls in November 2020; in the long term, whomever they vote for, most Americans understand that China is responsible for a global catastrophe that could have been greatly minimized or even averted entirely had Beijing simply told the truth about it from the beginning. No number of missteps, from often-bungling Western governments, can disguise Beijing’s fundamental culpability. Recent polls in the United States suggest that Americans understand this — overwhelming majorities blame China for causing this disaster. Moreover, the coronavirus has darkened Americans’ views of China more broadly. A Pew poll showed two-thirds of American respondents now view China negatively. American policymakers — regardless of whether they are part of a Trump or Joe Biden administration in 2021 — will have to respond to the American people’s darkening view of China. Even the most devout China apologists — and their numbers are legion in the federal government, in the private sector, and in the American media — will have to recognize that the coronavirus has ripped the curtain down on Beijing’s masquerade as a responsible member of the global community. China’s refusal to take responsibility for the virus has revealed the true character of the Communist regime even for those who had not been willing to acknowledge the obvious before. If U.S. officials, of either party, hope genuinely to serve the American national interest, then we’re going to see changes in the years ahead. Some of those changes are already afoot. The Trump administration has cut investment ties, for example, between U.S. federal retirement funds and Chinese equities. The move affects about $4 billion in assets. Meantime, U.S. lawmakers, in tandem with Canadian counterparts and Indian attorneys, are pursuing various legal actions, including reparations, against China for inflicting the coronavirus on the world, causing hundreds of thousands of deaths and hundreds of billions, if not trillions, in economic damage. Republican Senator Marsha Blackburn of Tennessee has sponsored a Senate resolution calling on Beijing to forgive some of its holdings of American debt. Private American citizens have filed lawsuits against China seeking damages, including a $20 trillion class-action suit in Texas. Beijing will pay no heed to Blackburn’s gesture, and the Foreign Sovereign Immunities Act will almost surely protect it against citizen claims, but these actions indicate the resentment against China felt by large portions of the American public. Some China observers, such as Gordon Chang, argue that the United States should retaliate by seizing China’s holdings of U.S. Treasury obligations — but only in tandem with our allies and issuers of other major currencies. “If we act alone,” Chang argues, “China is going to say that we repudiated our debt. We’re going to take a reputational hit, which is going to be a big one… they’re going to say that we are an irresponsible member of the global financial system, and that the dollar shouldn’t be the reserve currency of the world.” But if the U.S. acts in concert with allies, then “we can take away that argument from China.” The anger extends far beyond Washington’s shores. India’s bar association, in tandem with the International Council of Jurists (ICJ), is appealing to the United Nations Human Rights Council for compensation from China for “surreptitiously developing a biological weapon capable of mass destruction.” The ICJ’s president called Covid-19 a “crime against humanity,” caused by China, which has “deliberately concealed crucial information about coronavirus.” He asked the UN to “enquire and direct China and to adequately compensate international community and member states, particularly India, for surreptitiously developing a biological weapon capable of mass destruction of mankind.” He further alleged that China had exploited the virus with the intention of controlling the global economy and taking advantage of countries weakened by the virus and facing economic collapse.

Beijing’s shameful actions in regard to medical equipment and supplies, as well as testing materials — buying up these materials on the global market, thus causing shortages, and then selling everything from defective equipment to bad tests to countries facing virus outbreaks — has caused anger and resentment in capitals around the world. Several countries in Asia and Europe, including Great Britain and Spain, have sent these useless materials back to Beijing.And more recent steps in Washington reflect a broader awareness developing of the scope and range of the response needed.

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