COVID-19 long-term effects even mild cases
People report ongoing fatigue, brain fog and breathlessness, so what’s happening in the body?
By now, we’re getting a better understanding of what coronavirus disease looks like. We know COVID-19 can be a fairly mild flu-like illness for many people; some people don’t even know they have it. We also know that it can be deadly for others. It can have a range of serious health impacts, such as widespread blood clotting and strokes and, in some rare cases, cause an immune overreaction known as a cytokine storm. What’s less clear, however, are the longer-term health effects of COVID-19. It’s worth remembering it’s been less than nine months since the first cases of what we now know as COVID-19 emerged in Wuhan, China, so its long-term health effects are still impossible to know. But over the past few months, anecdotes have emerged of people experiencing strange, ongoing symptoms, including prolonged fatigue, breathlessness, brain fog and digestive issues. As with many aspects of the new coronavirus, researchers are trying to pull together data to understand the medium-term health effects more fully. COVID-19 “long-haulers”, as many of the people with prolonged symptoms are calling themselves, often describe ongoing exhaustion and shortness of breath.In part, this can be explained by the way the virus can seriously affect the lungs. The infection can cause fibrosis — scarred, stiff tissue that makes it difficult for the lungs to do their job of oxygenating the blood. But changes to the heart can also contribute to these symptoms, says Linda Gallo, who is researching how coronavirus affects the heart, especially in people with diabetes. Its impact on the heart still isn’t clear, Dr Gallo says, but studies published in recent weeks describe abnormalities in the hearts of patients who have completely cleared the virus. “[The researchers] asked them about their just general wellbeing and a lot of the patients are commenting on just being generally exhausted and having shortness of breath, some of them having palpitations, atypical chest pain,” she says. What’s more, many of these patients weren’t that sick with COVID-19 — most of them had managed their illness at home, rather than needing hospital treatment. “Overall, the authors state that the cardiac effects were independent of severity and course of acute infection — which is concerning,” Dr Gallo says. Dr Gallo is part of a study investigating the longer-term effects of COVID-19, especially on people with diabetes, and is currently looking for people who have had coronavirus to participate in a study. Based on the information already available, she and her colleagues expect people with diabetes (either type 1 or type 2) are more likely have long-term effects. Other persistent symptoms people report have to do with the brain: “brain fog”, sleeplessness and headaches. While we don’t fully understand the neurological effects of coronavirus yet, we can learn a lot from the way the brain responds to other infections, says neuroscientist Lila Landowski of the University of Tasmania. Fatigue, which is more than just a feeling of tiredness, and can be associated with things like a “foggy” brain, slowed reflexes and headaches, is usually a useful response to infections. “There’s a good reason for that — mounting an immune response to fight an infection takes a huge amount of energy,” Dr Landowski says. “The body wants you to do as little as possible, so you can conserve energy and divert it to the immune system. “Then, once the infection is eliminated, the fatigue dissipates. “However, in some people, the switch that returns the body back to normal seems to fail, resulting in chronic fatigue.” Researchers are trying to understand more about this “switch” in the hope of developing effective treatments for those with chronic fatigue.
We’ve never made a successful vaccine for a coronavirus before. This is why it’s so difficult
For those pinning their hopes on a COVID-19 vaccine to return life to normal, an Australian expert in vaccine development has a reality check — it probably won’t happen soon. The reality is that this particular coronavirus is posing challenges that scientists haven’t dealt with before, according to Ian Frazer from the University of Queensland. Professor Frazer was involved in the successful development of the vaccine for the human papilloma virus which causes cervical cancer — a vaccine which took years of work to develop. He said the challenge is that coronaviruses have historically been hard to make safe vaccines for, partly because the virus infects the upper respiratory tract, which our immune system isn’t great at protecting. And while we have vaccines for seasonal influenza, HPV and other diseases, creating a new vaccine isn’t as simple as taking an existing one and swapping the viruses, said Larisa Labzin, an immunologist from the University of Queensland. “For each virus or different bacterium that causes a disease, we need a different vaccine because the immune response that’s mounted is different,” Dr Labzin told ABC Science.
There are several reasons why our upper respiratory tract is a hard area to target a vaccine. “It’s a separate immune system, if you like, which isn’t easily accessible by vaccine technology,” Professor Frazer told the Health Report. Despite your upper respiratory tract feeling very much like it’s inside your body, it’s effectively considered an external surface for the purposes of immunisation. “It’s a bit like trying to get a vaccine to kill a virus on the surface of your skin.” Your skin, and the outer layer of cells in your upper respiratory tract act as a barrier to viruses, stopping them getting into the body. And finding a way to neutralise the virus “outside” of the body is very difficult. This is partly because only the outer layer of cells (the epthelial cells) get infected, which, compared to a severe infection of internal organs doesn’t produce the same immune response, so is harder to target. It’s hard to produce a successful vaccine if the virus isn’t activating a strong immune response.
“One of the problems with corona vaccines in the past has been that when the immune response does cross over to where the virus-infected cells are it actually increases the pathology rather than reducing it,” Professor Frazer said.
“So that immunisation with SARS corona vaccine caused, in animals, inflammation in the lungs which wouldn’t otherwise have been there if the vaccine hadn’t been given.”
Antibodies are proteins that are released by the immune system to neutralise a threat, like a virus. We’ve so far found with coronavirus that those infected have had different antibody responses, some weak, some strong. “I think it would be fair to say that the natural immunity that you get after infection from this coronavirus is probably going to turn out like the coronaviruses we’ve seen in the past.
At the moment, teams around the world are deploying different technologies in vaccine development, from killing the virus and using it in the vaccine like we do with influenza, to using messenger RNA to prompt the infected cells to produce antibodies. But the reality of vaccine development is that many fail before a successful one is developed.
This sort of vaccine was tested with SARS in 2003 and resulted in reinfected lab monkeys having a nasty immune response, which is why many groups working on a vaccine for Sars-CoV-2 are going for a very specific antibody response. Professor Frazer said the narrow, targeted approach is fine, unless you pick the wrong specific antigen — the substance that stimulates an immune response which antibodies bind to — in which case you could end up with the same problem. We don’t yet have vaccines against any coronaviruses in humans, in part due to the challenges of developing vaccines for viruses that infect the upper respiratory tract. There are a lot of vaccine experiments going on around the world at the moment trying to change that though, including some in human trials. Trials in humans will have to be fairly extensive before we would think about vaccinating a group of people who have not yet been exposed to the virus. Nick Bit: In this fast track hysteria their will be no No NO extensive human trails. Its slam bam ram it through and hide the disaster in the making!
“They might hope to get protection but certainly wouldn’t be keen to accept a possibility of really serious side effects if they actually caught the virus.”
Their has NEVER EVER been a successful RNA Vaccine
Pfizer and Moderna vaccines are unproven messenger RNA vaccines
American drugmaker Pfizer Inc, which had partnered with German biotech firm BioNTech to develop a vaccine candidate against Covid-19 earlier this year, has become the latest in the list of major movers in the vaccine race to move into the final stages of human trials. Both Modernaand Pfizer’s candidates belongs to a category called a messenger RNA vaccine. These types of vaccines involve modifying a messenger RNA to get the cells to recreate the part of the virus that is crucial to target. In this case, the Pfizer-BioNTech vaccine has modified the messenger RNA to instruct the cells in the body to produce the spiky outer surface of the SARS-CoV-2 virus–the spike glycoprotein. for approvals as early as October this year. If approval is given, the firm plans to supply up to 100 million doses by the end of 2020 and around 1.3 billion doses by the end of 2021“Fast Track” designation by the US Food and Drug Administration earlier this month. This would allow an expedited review and approval of their vaccine candidates when it approaches the regulator. Nick Note: They forgot to tell you their has NEVER EVER NEVER been a successful RNA vaccine. And in trials that failed the vaccines made people sick and killed a lot of people. Thats why they usually test them in third world shit holes among the poor and in dictatorships where their is no nasty free press to report the slaughter. TO FAST TRACK this unproven technology is a sign of the desperation of the politicians. Here is what you need to know:
- The mRNA strand in the vaccine may elicit an unintended immune reaction. To minimise this, the mRNA vaccine sequences are designed to mimic those produced by mammalian cells (for example monkey cells).[14]
- A possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with inflammation but also potentially with autoimmunity. Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA vaccination may allow reasonable precautions to be taken.[15] Nick Bit: it takes a decade or more to identify the high risk groups. Impossible to do in a fast track hysteric environment. This time the protocols that i have read do not address this critical issue
John Hopkins: Wide distribution of vaccines END of 2021
BALTIMORE (WJZ) – Johns Hopkins public health experts laid out challenges in distributing and administering coronavirus vaccines. “A vaccine isn’t going to work if you’re not going to receive it,” Dr. Naor Bar-Zeev of the Johns Hopkins Bloomber School of Public Health said. “Most likely, older adults will be prioritized. Health care workers will clearly be prioritized on the front line. The question then becomes what about essential workers? What about keeping the economy going?”
Moderna and Pfizer each started large-scale trials this week, the first in the U.S. NIAID Director Dr. Anthony Fauci said trials are moving at a rapid speed. Nick Bit: what they forgot to tell you is Phase II studies they just completed only involved 30 volunteers who were healthy and NOT a representative population.
“We want to make sure that we’re very transparent, that people appreciate that that speed is not compromising safety, nor is it compromising scientific integrity,” Dr. Fauci said. A reasonable timeline for wide distribution of vaccines is likely the end of 2021, according to Dr. Bar-Zeev. “Even after we have a vaccine that works and even after we demonstrate its safety and efficacy and even after we’ve produced enough doses to go around, at least for the first round, we still need to get it delivered and that’s going to be a big challenge,” Dr. Bar-Zeev said. “What we’re seeing is science live in real time. I think in the long run, that’s good for science and that’s good for community trust. In the short run, it leaves people feeling a little bit, say, uncomfortable.” Public faith in a vaccine may depend on politics, Dr. Monica Schoch-Spana of the Johns Hopkins Center for Health Security said. “We’re seeing this political partisanship playing out, sadly, also in terms of vaccine hesitancy,” Dr. Schoch-Spana said. “For some, they may be anxious on whether a COVID-19 vaccine is safe and effective. Others may be mistrustful.” Dr. Schoch-Spana called on more federal leaders to commit any vaccine be free and available. “We need the government to publically pledge that everyone that wants a vaccine can get one,” Dr. Schoch-Spana said. Dr. Bar-Zeev said older adults and health care workers will likely be prioritized over others once vaccines are approved. Nick Note: the hype and hope is unbelievable. I have heard Trump yes men proclaim the vaccine will be 95% t effective. their is NO data to support this claim. They are talking widespread distribution by the end of this year and early next year…… This is some crazy DANGEROUS shit!
Dr. Fauci said wide distribution of vaccines is end of 2021
BALTIMORE (WJZ) – Johns Hopkins public health experts laid out challenges in distributing and administering coronavirus vaccines. “A vaccine isn’t going to work if you’re not going to receive it,” Dr. Naor Bar-Zeev of the Johns Hopkins Bloomber School of Public Health said. “Most likely, older adults will be prioritized. Health care workers will clearly be prioritized on the front line. The question then becomes what about essential workers? What about keeping the economy going?” Moderna and Pfizer each started large-scale trials this week, the first in the U.S. NIAID Director Dr. Anthony Fauci said trials are moving at a rapid speed. “We want to make sure that we’re very transparent, that people appreciate that that speed is not compromising safety, nor is it compromising scientific integrity,” Dr. Fauci said. A reasonable timeline for wide distribution of vaccines is likely the end of 2021, according to Dr. Bar-Zeev. “Even after we have a vaccine that works and even after we demonstrate its safety and efficacy and even after we’ve produced enough doses to go around, at least for the first round, we still need to get it delivered and that’s going to be a big challenge,” Dr. Bar-Zeev said. “What we’re seeing is science live in real time. I think in the long run, that’s good for science and that’s good for community trust. In the short run, it leaves people feeling a little bit, say, uncomfortable.”
Public faith in a vaccine may depend on politics, Dr. Monica Schoch-Spana of the Johns Hopkins Center for Health Security said. “We’re seeing this political partisanship playing out, sadly, also in terms of vaccine hesitancy,” Dr. Schoch-Spana said. “For some, they may be anxious on whether a COVID-19 vaccine is safe and effective. Others may be mistrustful.” Dr. Schoch-Spana called on more federal leaders to commit any vaccine be free and available. “We need the government to publically pledge that everyone that wants a vaccine can get one,” Dr. Schoch-Spana said. Dr. Bar-Zeev said older adults and health care workers will likely be prioritized over others once vaccines are approved.
Pompeo: DoJ to decide on election postponement
Secretary of State Mike Pompeo responded cautiously when asked during a congressional hearing on Thursday about President Donald Trump’s tweet suggesting a delay to the presidential election in November. “I’m not going to enter a legal judgement on the fly this morning,” Pompeo told Sen. Tim Kaine during a Senate Foreign Relations Committee hearing, after the Virginia Democrat asked about Trump’s tweet. “In the end, the DOJ, others, will make that legal determination.” But Pompeo’s reference to the Department of Justice injected a new element into the proposal. The secretary of state, a former editor of the Harvard Law Review and later a lawyer for the elite Washington, D.C.-based firm Williams & Connolly, did not elaborate on what role the agency could play. He said only that the election should be carried out “lawfully.” “We want to have an election that everyone is confident in,” Pompeo said, declining to answer Kaine’s explicit question about how Trump could legally postpone the election. “It should happen lawfully.” Trump on Thursday pinned a tweet to the top of his account taking aim at proposals for greater mail-in voting to protect Americans against spreading the coronavirus. He did not offer evidence that mail-in voting leads to greater fraud, a claim he has frequently repeated “With Universal Mail-In Voting (not Absentee Voting, which is good), 2020 will be the most INACCURATE & FRAUDULENT Election in history,” Trump tweeted Thursday. “It will be a great embarrassment to the USA. Delay the Election until people can properly, securely and safely vote???” The Trump tweet and the Pompeo exchange come after Attorney General William Barr declined to answer a question about delaying the election following previous suggestions from Trump that he would do so. Testifying before the House Judiciary Committee on Tuesday, Barr said he had not “studied” the question of whether a president could move the election date. “I’ve never been asked the question before, I’ve never looked into it,” Barr told the committee.ed.
Coronavirus Report Card and the US leads the way!
Highlighted in green
= all cases have recovered from the infection
Highlighted in grey
= all cases have had an outcome (there are no active cases)
Radio Free Wall Street
Trump Will Be Delaying The Elections
Donald Trump knows he’ll lose the elections. He knows there will be no vaccine. If he can postpone the elections long enough for the population to be vaccinated, he can declare a victory over the Coronavirus and maybe slide back in. By the time the people figure out the vaccine doesn’t work, he’ll be elected again. This is an Earth shaking event and I lay it out for you in this Radio Free Wall Street broadcast.
Trump floats November election delay
Donald Trump has suggested November’s presidential election be postponed, saying increased postal voting could lead to fraud and inaccurate results.He floated a delay until people could “properly, securely and safely” vote. There is little evidence to support Mr Trump’s claims but he has long railed against mail-in voting which he has said would be susceptible to fraud.
US states want to make postal voting easier due to public health concerns over the coronavirus pandemic.
Under the US constitution, Mr Trump does not have the authority to postpone the election himself. Any delay would have to be approved by Congress. The president does not have direct power over the two houses of Congress. In a series of tweets, Mr Trump said “universal mail-in voting” would make November’s vote the “most inaccurate and fraudulent election in history” and a “great embarrassment to the USA”.
“The [Democrats] talk of foreign influence in voting, but they know that Mail-In Voting is an easy way for foreign countries to enter the race,” he said. Mr Trump also said postal voting was “already proving to be a catastrophic disaster” in areas where it was being tried out. In June, New York allowed voters to vote by post in the Democratic primary poll for the party’s presidential candidate. But there have been long delays in counting the ballots and the results are still unknown. US media report that there are also concerns that many ballots will not be counted because they were not filled in correctly or do not have postmarks on them that show they were sent before voting officially ended. Mr Trump appears to be doing everything in his power to undermine the credibility of November’s vote, in which a record number of Americans are predicted to rely on mail-in voting to avoid the risk of exposure to the coronavirus. He’s repeatedly made false and misleading claims about the reliability of the mail balloting and suggested broad conspiracy theories. Critics warn that he could be laying the groundwork for contesting the results – although the purpose may be simply to give him a scapegoat if he loses. Tweeting about an election delay is not the move of a candidate confident of victory – and could be a sign of more desperate moves to come.
Quizzed by reporters on whether a president could delay the election, Secretary of State Mike Pompeo said he would not “enter a legal judgement on the fly”. When pressed, he said the justice department would “make that legal determination”, adding “we want an election that everyone is confident in”.. Legal experts quoted by NBC said that even if Congress did agree to delay the election, Mr Trump’s own term as president would still expire by 20 January 2021 under the constitution’s 20th Amendment.
Earlier this month, six US states were planning to hold “all-mail” ballot elections in November: California, Utah, Hawaii, Colorado, Oregon and Washington. Other states are considering it, according to a postal voting campaign group. These states will automatically send postal ballots to all registered voters, which then have to be sent back or dropped off on election day – although some in-person voting is still available in certain limited circumstances. About half of US states allow any registered voter to cast their ballot by post on request. Critics of postal voting argue that people could vote more than once via absentee ballots and in person. Mr Trump has in the past said there was a risk of “thousands and thousands of people sitting in somebody’s living room, signing ballots all over the place”.